255 research outputs found

    On periodic cohort solurions of a size-structured population model

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    We consider a size-structured population model with discontinuous reproduction and feedback through the environmental variable ``substrate''. The model admits solutions with finitely many cohorts and in that case the problem is described by a system of ODEs involving a bifurcation parameter betabeta. Existence of nontrivial periodic nn-cohort solutions is investigated. Moreover, we discuss the question whether nn cohorts (nge2n ge 2) with small size differences will tend to a periodic one-cohort solution as ttoinftyt to infty

    A modified electromagnetism-like algorithm based on a pattern search method

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    The Electromagnetism-like (EM) algorithm, developed by Birbil and Fang [2] is a population-based stochastic global optimization algorithm that uses an attraction-repulsion mechanism to move sample points towards optimality. A typical EM algorithm for solving continuous bound constrained optimization problems performs a local search in order to gather information for a point, in the population. Here, we propose a new local search procedure based on the original pattern search method of Hooke and Jeeves, which is simple to implement and does not require any derivative information. The proposed method is applied to different test problems from the literature and compared with the original EM algorithm.(undefined

    A hybrid multiagent approach for global trajectory optimization

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    In this paper we consider a global optimization method for space trajectory design problems. The method, which actually aims at finding not only the global minimizer but a whole set of low-lying local minimizers(corresponding to a set of different design options), is based on a domain decomposition technique where each subdomain is evaluated through a procedure based on the evolution of a population of agents. The method is applied to two space trajectory design problems and compared with existing deterministic and stochastic global optimization methods

    Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

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    Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stably expressing the GH receptor (293GHR), HuH7 (hepatoma) and T-47D (breast cancer) cells. 293GHR cells were transiently transfected with an estrogen receptor-α expression plasmid and luciferase reporters with binding elements for STAT3 and STAT5 or the ÎČ-casein promoter. GH stimulated the reporter activities by four- to sixfold. Cotreatment with 17ÎČ-estradiol (E2) resulted in a dose-dependent reduction in the response of all three reporters to GH to a maximum of 49-66% of control at 100 nM (P < 0.05). No reduction was seen when E2 was added 1-2 h after GH treatment. Similar inhibitory effects were observed in HuH7 and T-47D cells. E2 suppressed GH-induced JAK2 phosphorylation, an effect attenuated by actinomycin D, suggesting a requirement for gene expression. Next, we investigated the role of the suppressors of cytokine signaling (SOCS) in E2 inhibition. E2 increased the mRNA abundance of SOCS-2 but not SOCS-1 and SOCS-3 in HEK293 cells. The inhibitory effect of E2 was absent in cells lacking SOCS-2 but not in those lacking SOCS-1 and SOCS-3. In conclusion, estrogen inhibits GH signaling, an action mediated by SOCS-2. This paper provides evidence for regulatory interaction between a sex steroid and the GH/JAK/STAT pathway, in which SOCS-2 plays a central mechanistic role
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